Thermo Fisher Scientific Inc. unveiled the Thermo Scientific Arctis Cryo-Plasma Focused Ion Beam (Cryo-PFIB), a new connected and automated microscope designed to advance the pace of cryo-electron tomography (cryo-ET) research. Cryo-ET makes it possible to study how proteins and other molecules operate together in a cellular context, at resolutions unsurpassed by other microscopy techniques, and has enormous potential for cell biology research, including the study of infectious disease, neurodegenerative disease, and other globally impactful structural biology applications. However, the process of preparing optimal samples for cryo-ET is still time-consuming and complex.

Around a mile below the surface in South Dakota, construction crews are hard at work excavating around 1,000 tons of rock per day. Their goal is to make room for a large underground facility that will house an international effort aimed at studying neutrinos—highly elusive subatomic particles that may hold the key to many of the universe’s secrets.

Two space tech companies, Helios and Eta Space, announced they are joining forces to solve the problem of oxygen in space. If humanity is to have a sustainable presence beyond Earth, reusable methane-fueled rocket systems need liquid oxygen at a ratio of 1:4, so the only cost-effective solution to refueling in orbit is to create and store oxygen on the Moon and on Mars.

Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics. 

Previously, it has been impossible to capture the high-resolution images of nitrogenase, the only enzyme capable of reducing nitrogen into ammonia, during catalytic action. Now, for the first time, researchers at the University of California San Diego report near-atomic-resolution snapshots of nitrogenase during catalysis using cryogenic electron microscopy (cryoEM). The results were published in the journal Science.

To journey and return from other planets, future spacecraft may have to do something they've never done before: refuel in space. Thanks to a Purdue University experiment, scientists are now beginning to understand how cryogenic liquids behave in zero-gravity, and how this affects the future operation of propellant depots in space. 

Vacuum technologies have advanced the field of cryogenics, allowing researchers to push the frontiers of what we know and businesses to apply that knowledge and drive innovation across a wide range of industries. The intersection of vacuum and cryogenic sciences is a demanding one. Pressure and temperature requirements create a playing field where only certain materials of construction and precise techniques and processes can play. Whether a component within a closed cryogenic system or a transfer link to be reused and repurposed, metal hoses are well suited for these exacting environments.

by Michael Werner, Project Scientist, Spitzer Space Telescope—Jet Propulsion Laboratory, California Institute of Technology 

NASA’s Spitzer Space Telescope, launched in August 2003 and decommissioned in January 2020 after more than 16 glorious years of exploration of the universe at infrared wavelengths, was a technical and scientific marvel. Infrared astronomical studies at wavelengths longward of 1 micron, somewhat beyond the limit of human vision at around 0.7 microns, began in earnest around 1960. These early studies, carried out on ambient temperature telescopes within the atmosphere, advanced astronomical understanding of targets from planets within the solar system to distant and highly luminous galaxies. However, they could not disguise the fact that the earth is a hostile environment for infrared astronomy.

Recently, NIRISS, one of NASA’s James Webb Space Telescope’s four primary scientific instruments concluded its postlaunch preparations and was declared ready for science. Now a second of Webb’s four primary scientific instruments, known as the Mid-Infrared Instrument (MIRI), has also concluded its postlaunch preparations and is now ready for science.

Theoretical physics is full of weird and wonderful concepts: wormholes, quantum foam and multiverses, just to name a few. The problem is that while such things easily emerge from theorists’ equations, they are practically impossible to create and test in a laboratory setting. But for one such “untestable” theory, an experimental setup might be just on the horizon. 

NASA’s James Webb Space Telescope has delivered the deepest and sharpest infrared image of the distant universe so far. Webb’s First Deep Field is galaxy cluster SMACS 0723, and it is teeming with thousands of galaxies – including the faintest objects ever observed in the infrared. 

Researchers at the Max-Planck Institute for Nuclear Physics in Germany and the Columbia Astrophysics Laboratory have recently carried out an experiment aimed at measuring the rate of quantum transitions caused by collisions between molecules and electrons. Their findings, published in Physical Review Letters, offer the first experimental evidence of this rate, which had previously only been theoretically estimated.

Ryan Day studies superconductors. Materials that conduct electricity perfectly, losing no energy to heat and resistance. Specifically, the University of California, Berkeley scientist studies how superconductors can coexist with their opposites; insulating materials that stop the flow of electrons. The materials that combine these two opposed states, called topological superconductors, are understandably weird, hard to characterize and engineer, but if one could design them properly, they could play an important role in quantum computing.

In biology, getting rid of stuff can be just as important as making it. A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house. A prime example is the RNA exosome. RNA molecules perform many roles in cells. Some of them are translated into proteins; others form a cell’s protein-building machinery. The RNA exosome is a cellular machine that degrades RNA molecules that are faulty, harmful, or no longer needed. Without this microscopic Marie Kondo to prune what doesn’t spark joy, our cells would become dysfunctional hoarders, unable to function.

Scientists are about to get a new look at Mars, thanks to a multicolored 5.6-gigapixel map. Covering 86% of the Red Planet’s surface, the map reveals the distribution of dozens of key minerals. By looking at mineral distribution, scientists can better understand Mars’ watery past and can prioritize which regions need to be studied in more depth.